بررسی اثرات پیش داروی پره گابالین در مقایسه با دارونما بر درد حاد پس از هیسترکتومی شکمی

Background and aims: Although pregabalin is primarily an anticonvulsive drug and is alsoeffective on chronic neuropathic pain, there are limited data regarding its effect on acute pain. Inthis study we assessed the analgesic effect of pregabalin on acute post operative pain used aspreemptive analgesia in comparison to placebo and compared pain intensity and opiumrequirements among placebo and pregabalin group.Methods and materials: 60 females who scheduled for TAH in Rasoul -Akram hospital werechosen, aged between 30-70, and weighted between 60 - 80 kg. Thirty had taken oral pregabalin(300) mg one hour pre surgical procedure, the others received placebo. Pain level and doses ofopioid substance were compared between two groups at 4, 8, 12, 16, 20 and 24 hours aftersurgery. Agitation status, nausea, vomiting and dizziness were also recorded and compared.Results: Pain level at 12, 20, 24 hours were significantly lower in the pregabalin group.Meperidin needed dosage and agitation level was reduced in the pregabalin group (p < 0.0001).Nausea and vomiting had no difference between two groups. Dizziness was higher in pregabalingroup (p = 0.03).Conclusion: Pregabalin as a preemptive drug before surgery can reduce postoperative pain andagitation. However can increase some complications like dizziness.